Article

Endocrine-exocrine signaling drives obesity-associated pancreatic ductal adenocarcinoma

2019-06-21

Abstract excerpt

<h4>SUMMARY</h4> Obesity is a major modifiable risk factor for pancreatic ductal adenocarcinoma (PDAC), yet how and when obesity contributes to PDAC progression is not well understood. Leveraging an autochthonous mouse model, we demonstrate a causal and reversible role for obesity in early PDAC progression, showing that obesity markedly enhances tumorigenesis, while genetic or dietary induction of weight loss int...

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Literature Corpus work: 06cbb30f-0374-5128-9278-7bee0aca02f7
DOI: 10.1101/663583

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