Targeting PIKfyve-driven lipid homeostasis as a metabolic vulnerability in pancreatic cancer

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) subsists in a nutrient-deregulated microenvironment, making it particularly susceptible to treatments that interfere with cancer metabolism 1 2 . For example, PDAC utilizes and is dependent on high levels of autophagy and other lysosomal processes 3-5 . Although targeting these pathways has shown potential in preclinical studies, progress has been hampered by the challenge...

Topics

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• Autophagy in Disease and Therapy
• Cell Compartmentation
• Deoxycytidine
• Extracellular Signal-Regulated MAP Kinases
• Gemcitabine
• MAP Kinase Signaling System
• Pancreatic function and diabetes
• Protein Degradation and Inhibitors

Identifiers and source

Literature Corpus work

83d264d6-5d67-51b5-a5dd-030dd6a3c669

DOI

10.1101/2024.03.18.585580