Article

PCSK9 dependent cholesterol acquisition and utilization underlies metastatic organ preference in pancreatic cancer

2025-04-25

Abstract excerpt

To grow at distant sites, metastatic cells must overcome major challenges posed by the unique cellular and metabolic composition of secondary organs 1 . Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease that metastasizes to the liver and lungs. Despite evidence of metabolic reprogramming away from the primary site, the key drivers that dictate the ability of PDAC cells to colonize the liver or lung...

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Identifiers and source

Literature Corpus work: 904faa6b-1424-5236-a6e5-0e6578101075
DOI: 10.1101/2025.04.22.649912

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