Article
Concurrent PEDF deficiency and Kras mutation induce invasive pancreatic cancer and adipose-rich stroma in mice.
Gut - 1 Oct 2012
Grippo Paul J, Fitchev Philip S, Bentrem David J, Melstrom Laleh G, Dangi-Garimella Surabhi, Krantz Seth B, Heiferman Michael J, Chung Chuhan, Adrian Kevin, Cornwell Mona L, Flesche Jan B, Rao Sambasiva M, Talamonti Mark S, Munshi Hidayatullah G, Crawford Susan E
Abstract excerpt
BACKGROUND AND AIMS: Pigment epithelium-derived factor (PEDF), a non-inhibitory SERPIN with potent antiangiogenic activity, has been recently implicated in metabolism and adipogenesis, both of which are known to influence pancreatic cancer progression. Increased pancreatic fat in human pancreatic tumour correlates with greater tumour dissemination while PEDF deficiency in mice promotes pancreatic hyperplasia and...
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