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Elevated SREBP1 accelerates the initiation and growth of pancreatic cancer by targeting SOX9

13 Jan 2025

Abstract excerpt

Pancreatic cancer is a lethal disease with an insidious onset, and little is known about its early molecular events. Here, we found that the sterol regulatory element-binding protein 1 (SREBP1) expression is gradually upregulated during the initiation of pancreatic cancer. Through in vitro 3D culture of pancreatic acinar cells and experiments in LSL-Kras G12D/+ ; Pdx1-Cre (KC) mice, we found that pharmacological...

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Caveolin-1 and cellular processes
Cholesterol and Lipid Metabolism
MicroRNA in disease regulation

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39806513
DOI: 10.1186/s13062-025-00595-1

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