Article

Alzheimer’s disease BIN1 coding variants increase intracellular Aβ by interfering with BACE1 recycling

2021-06-10

Abstract excerpt

<h4>ABSTRACT</h4> Genetics identified BIN1 as the second most important risk locus associated with late-onset Alzheimer’s disease, after APOE4. Here we show the consequences of two coding variants in BIN1 (rs754834233 and rs138047593), both in terms of intracellular beta-amyloid accumulation (iAbeta) and early endosome enlargement, two interrelated early cytopathological Alzheimer’s disease phenotypes, supportin...

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Literature Corpus work: 88e55e7e-204d-5c10-8eb5-b92b882c546b
DOI: 10.1101/2021.06.09.447716

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