Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alzheimer's disease BIN1 coding variants increase intracellular Aβ levels by interfering with BACE1 recycling.

The Journal of biological chemistry - 1 Sept 2021

Perdigão Catarina, Barata Mariana A, Burrinha Tatiana, Guimas Almeida Cláudia

Abstract excerpt

Genetic studies have identified BIN1 as the second most important risk locus associated with late-onset Alzheimer's disease (LOAD). However, it is unclear how mutation of this locus mechanistically promotes Alzheimer's disease (AD) pathology. Here we show the consequences of two coding variants in BIN1 (rs754834233 and rs138047593), both in terms of intracellular beta-amyloid (iAbeta) accumulation and early...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Adaptor Proteins, Signal Transducing
Share to Amyloid beta-Peptides
Share to Amyloid Precursor Protein Secretases
Share to Aspartic Acid Endopeptidases
Share to Endosomes
Share to Mice, Inbred BALB C
Share to Protein Transport
Share to Tumor Suppressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 34375641
DOI: 10.1016/j.jbc.2021.101056
PMCID: PMC8413894

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alzheimer's disease BIN1 coding variants increase intracellular Aβ levels by interfering with BACE1 recycling.PMID 34375641Read ↗

Alzheimer’s disease BIN1 coding variants increase intracellular Aβ by interfering with BACE1 recyclingSemantic proximity Read ↗

Aberrant accrual of BIN1 near Alzheimer’s disease amyloid deposits in transgenic modelsSemantic proximity Read ↗

BIN1 regulates BACE1 intracellular trafficking and amyloid-β productionSemantic proximity Read ↗

Bridging integrator 1 (BIN1): form, function, and Alzheimer's disease.Semantic proximity Read ↗

BIN1 Is Decreased in Sporadic but Not Familial Alzheimer’s Disease or in AgingSemantic proximity Read ↗

The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defectsSemantic proximity Read ↗

Alzheimer’s genetic risk factor Bin1 controls synapse vesicle exo-endocytosis in inhibitory synapsesSemantic proximity Read ↗

The Alzheimer susceptibility gene <i>BIN1</i> induces isoform-dependent neurotoxicity through early endosome defectsSemantic proximity Read ↗

The recycling endosome biogenesis machinery coordinates BACE1 endosomal sorting and amyloid-β productionSemantic proximity Read ↗

Bridging integrator 1 protein loss in Alzheimer’s disease promotes synaptic tau accumulation and disrupts tau releaseSemantic proximity Read ↗

RIN3 mutations impairing binding of the Alzheimer's disease-associated protein BIN1 lead to RAB5 hyperactivation and endosomal pathology.Semantic proximity Read ↗

Impact of late-onset Alzheimer's genetic risk factors on beta-amyloid endocytic production.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.