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Article

BIN1 regulates BACE1 intracellular trafficking and amyloid-β production

14 May 2016

Abstract excerpt

BIN1 is a genetic risk factor of late-onset Alzheimer disease (AD), which was identified in multiple genome-wide association studies. BIN1 is a member of the amphiphysin family of proteins, and contains N-terminal Bin-Amphiphysin-Rvs and C-terminal Src homology 3 domains. BIN1 is widely expressed in the mouse and human brains, and has been reported to function in the endocytosis and the endosomal sorting of...

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PMID: 27179792
DOI: 10.1093/hmg/ddw146

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