Article
Large extracellular vesicles containing mitochondria (EVMs) derived from Alzheimer’s disease cells harbor pathologic functional and molecular profiles and spread mitochondrial dysfunctions
2025-02-13
Abstract excerpt
<title>Abstract</title> <p>In addition to small extracellular vesicles known as exosomes, cells release large extracellular vesicles containing mitochondria (EVMs). The molecular and functional characteristics of EVMs, as well as the impact of EVMs on the spreading of mitochondrial dysfunction between cells, remain unknown in the context of Alzheimer’s Disease (AD). Here, we provide an ultrastructural, biochemica...
Topics
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- Alzheimer's disease research and treatments
- Amyotrophic Lateral Sclerosis Research
- Autophagy in Disease and Therapy
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Neurogenetic and Muscular Disorders Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
Identifiers and source
- Literature Corpus work
- d315e521-bb78-5e52-add0-8ec26c733cbb
- DOI
- 10.21203/rs.3.rs-5932075/v1
