Article

The exocyst is an insulin-sensitive regulator of amyloid precursor protein trafficking and amyloid-beta generation in neurons

2026-04-17

Abstract excerpt

<h4>SUMMARY</h4> Intracellular trafficking of amyloid precursor protein (APP) critically influences amyloidogenic processing, yet the mechanisms regulating this pathway remain incompletely defined. The exocyst is a highly conserved, insulin-responsive, eight-protein Rab effector complex that directs intracellular transport vesicle targeting and docking. We identified APP in a proteomics screen of neuronal cell su...

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Literature Corpus work: b393943a-ed19-5d7f-ad43-8543be05dc75
DOI: 10.64898/2026.04.14.717551

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