Article

The amyloid precursor protein and its derived fragments concomitantly contribute to the alterations of mitochondrial transport machinery in Alzheimer’s disease

2023-09-21

Abstract excerpt

<title>Abstract</title> <p>Mitochondria dysfunctions and mitophagy failure have been associated with several Alzheimer’s disease (AD) related molecular actors including amyloid beta (Aβ) and recently the amyloid precursor protein-C terminal fragments (APP-CTFs). The efficacy of the mitophagy process in neurons relies on regulated mitochondrial transport along axons involving a complex molecular machinery. The con...

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Literature Corpus work: 5bd6fbd6-374d-5d5b-9bf3-abb5050fc567
DOI: 10.21203/rs.3.rs-3235215/v1

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