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Alzheimer’s disease PSEN-2 N141I variant alters trafficking of amyloid beta oligomers in iPSC-derived brain endothelial-like cells

2026-02-23

Abstract excerpt

<title>Abstract</title> <p>Intracellular trafficking of amyloid beta oligomers (AβO) in a stem cell-derived brain endothelial-like cell (BEC) model of Alzheimer’s disease (AD) was investigated. Healthy control BECs demonstrated co-localization of cytotoxic AβO in lysosomal compartments whereas AβO was sequestered to late endosomes in AD-BECs. Inhibition of lysosomal activity exacerbated toxicity of AβO in control...

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Literature Corpus work
78897215-4b90-507f-b9e1-9272367508ae
DOI
10.21203/rs.3.rs-8787446/v1
Open publication

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Alzheimer’s disease PSEN-2 N141I variant alters trafficking of amyloid beta oligomers in iPSC-derived brain endothelial-like cellsDOI 10.21203/rs.3.rs-8787446/v1
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