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APP and β-amyloid modulate protein aggregation and dissociation from recycling endosomal and exosomal membranes

2024-03-30

Abstract excerpt

<h4>Summary</h4> Secretory proteins frequently aggregate into non-soluble dense-core granules (DCGs) in recycling endosome-like compartments prior to release. By contrast, aberrantly processed Aβ-peptides derived from Amyloid Precursor Protein (APP) form pathological amyloidogenic aggregations in late-stage Alzheimer’s Disease (AD) after secretion. By examining living Drosophila prostate-like secondary cells, we...

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Literature Corpus work
5874dcf5-4559-50f8-9541-9eafa9ccc4ed
DOI
10.1101/2024.03.28.586966
Open publication

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APP and β-amyloid modulate protein aggregation and dissociation from recycling endosomal and exosomal membranesDOI 10.1101/2024.03.28.586966
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