Article

Cerebellar granule neurons induce Cyclin D1 in an early stage of Huntington’s disease

2022-11-09

Abstract excerpt

<h4>ABSTRACT</h4> Although Huntington’s disease (HD) is predominantly defined by selective vulnerability of striatal projection neurons, there is increasing evidence that cerebellar degeneration modulates clinical symptoms. However, little is known about cell type-specific responses of cerebellar neurons in HD. To dissect early disease mechanisms in the cerebellum and cerebrum, we analyzed translatomes of neurona...

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Literature Corpus work: 837d5ef6-db08-58c4-9b7e-04cc28488cea
DOI: 10.1101/2022.11.08.515613

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