Article

Striatal pathology in Spinocerebellar Ataxia Type 1 mice: A comparative study with Huntington’s disease

2025-12-14

Abstract excerpt

<h4>ABSTRACT</h4> Spinocerebellar ataxia type 1 (SCA1) and Huntington’s disease (HD), are motor diseases caused by CAG expansions in ATXN1 and HTT , where SCA1 shows prominent cerebellar neurodegeneration and HD shows prominent striatal neurodegeneration, particularly in the Medium Spiny Neurons (MSNs). Since human and mouse studies demonstrate progressive striatal vulnerability in SCA1, we examined age-depende...

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Literature Corpus work: 2594157e-602d-525c-a58a-c4bac60dc8a8
DOI: 10.64898/2025.12.11.693749

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