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Article

Structures of monomeric and dimeric PRC2:EZH1 reveal flexible modules involved in chromatin compaction.

Nature communications - 29 Jan 2021

Grau Daniel, Zhang Yixiao, Lee Chul-Hwan, Valencia-Sánchez Marco, Zhang Jenny, Wang Miao, Holder Marlene, Svetlov Vladimir, Tan Dongyan, Nudler Evgeny, Reinberg Danny, Walz Thomas, Armache Karim-Jean

Abstract excerpt

Polycomb repressive complex 2 (PRC2) is a histone methyltransferase critical for maintaining gene silencing during eukaryotic development. In mammals, PRC2 activity is regulated in part by the selective incorporation of one of two paralogs of the catalytic subunit, EZH1 or EZH2. Each of these enzymes has specialized biological functions that may be partially explained by differences in the multivalent...

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Identifiers

PMID: 33514705
DOI: 10.1038/s41467-020-20775-z
PMCID: PMC7846606

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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