Article
Single-molecule and in silico dissection of the interaction between Polycomb repressive complex 2 and chromatin.
Proceedings of the National Academy of Sciences of the United States of America - 1 Dec 2020
Leicher Rachel, Ge Eva J, Lin Xingcheng, Reynolds Matthew J, Xie Wenjun, Walz Thomas, Zhang Bin, Muir Tom W, Liu Shixin
Abstract excerpt
Polycomb repressive complex 2 (PRC2) installs and spreads repressive histone methylation marks on eukaryotic chromosomes. Because of the key roles that PRC2 plays in development and disease, how this epigenetic machinery interacts with DNA and nucleosomes is of major interest. Nonetheless, the mechanism by which PRC2 engages with native-like chromatin remains incompletely understood. In this work, we employ...
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