Back to search

Article

The novel HP1a interactor Clump/CG30403 safeguards transposon silencing and reproductive resilience in the <i>Drosophila</i> ovary

2026-07-16

Abstract excerpt

Heterochromatin and its core effectors from the Heterochromatin Protein 1 (HP1) family are essential for epigenetic silencing of repetitive regions and genome integrity from yeast to humans. However, how HP1s and associated factors regulate heterochromatin properties in vivo to sustain silencing across development, aging, and environmental factors, remains incompletely understood. Here, we identify Clump/CG30403...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
32fb8213-fd8e-5e1a-ae44-0977c3d532b7
DOI
10.64898/2026.07.15.738798
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
The novel HP1a interactor Clump/CG30403 safeguards transposon silencing and reproductive resilience in the <i>Drosophila</i> ovaryDOI 10.64898/2026.07.15.738798
A team of heterochromatin factors collaborates with small RNA pathways to combat repetitive elements and germline stressSemantic proximity
Drosophila <i>small ovary</i> gene ensures germline stem cell maintenance and differentiation by silencing transposons and organising heterochromatinSemantic proximity
piRNA loss unleashes episodic transposition burstsSemantic proximity
<i>putzig</i> safeguards genome integrity by contributing to the Piwi-mediated repression of transposon activity in the female germline of <i>Drosophila</i> in a two-tiered fashionSemantic proximity
Heterochromatin-dependent transcription of satellite DNAs in the <i>Drosophila melanogaster</i> female germlineSemantic proximity
In the <i>Drosophila</i> germline H2Av and Arp6 suppress transposons by driving piRNA pathway expressionSemantic proximity
DNA Methylation and Histone H1 Jointly Repress Transposable Elements and Aberrant Intragenic Transcripts.Semantic proximity
Stonewall prevents expression of testis-enriched genes and binds to insulator elements in <i>D. melanogaster</i>Semantic proximity
The Drosophila OSC Genome: A Resource for Studies of Transposon and piRNA BiologySemantic proximity
L1 and B1 repeats blueprint the spatial organization of chromatinSemantic proximity
Recurrent Gene Duplication Diversifies Genome Defense Repertoire in Drosophila.Semantic proximity
Mod(mdg4) variants repress telomeric retrotransposon <i>HeT-A</i> by blocking subtelomeric enhancersSemantic proximity
Select a neighboring publication to make it the new centre.