Article

Live cell imaging and CLEM reveals effects of Mutant Huntingtin Aggregation Process

2023-01-30

Abstract excerpt

Huntington’s disease is a neurodegenerative disease caused by expansion of CAG repeats in exon-1 of Huntingtin (HTT) gene leading to production of mutant Huntingtin (mHtt) protein. Htt protein is known to play crucial roles in regulation of cytoskeletal dynamics and vesicular transport in physiological conditions. By combining in vitro time-lapse imaging and correlative light and electron microscopy (CLEM), we i...

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Literature Corpus work: a84c9b96-895c-5b32-b5b9-f8c5126c4edd
DOI: 10.1101/2023.01.28.526012

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