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Article

Cryo-electron tomography provides topological insights into mutant huntingtin exon 1 and polyQ aggregates.

Communications biology - 8 Jul 2021

Galaz-Montoya Jesús G, Shahmoradian Sarah H, Shen Koning, Frydman Judith, Chiu Wah

Abstract excerpt

Huntington disease (HD) is a neurodegenerative trinucleotide repeat disorder caused by an expanded poly-glutamine (polyQ) tract in the mutant huntingtin (mHTT) protein. The formation and topology of filamentous mHTT inclusions in the brain (hallmarks of HD implicated in neurotoxicity) remain elusive. Using cryo-electron tomography and subtomogram averaging, here we show that mHTT exon 1 and polyQ-only aggregates...

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Identifiers

PMID: 34239038
DOI: 10.1038/s42003-021-02360-2
PMCID: PMC8266869

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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