Article

CryoET Reveals Organelle Phenotypes in Huntington Disease Patient iPSC-Derived and Mouse Primary Neurons

2022-03-27

Abstract excerpt

Huntington’s Disease (HD) is caused by an expanded CAG repeat in the huntingtin gene, yielding a Huntingtin protein with an expanded polyglutamine tract. Patient-derived induced pluripotent stem cells (iPSCs) can help understand disease; however, defining pathological biomarkers is challenging. Here, we used cryogenic electron tomography to visualize neurites in HD patient iPSC-derived neurons with varying CAG rep...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b6220de0-3701-5214-bb03-7f7cbe0c4f59
DOI: 10.1101/2022.03.26.485912

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CryoET Reveals Organelle Phenotypes in Huntington Disease Patient iPSC-Derived and Mouse Primary NeuronsDOI 10.1101/2022.03.26.485912Read

CryoET reveals organelle phenotypes in huntington disease patient iPSC-derived and mouse primary neurons.Semantic proximity Read

CryoET Reveals Organelle Phenotypes in Huntington Disease Patient iPSC-Derived and Mouse Primary NeuronsSemantic proximity Read

Cryo-electron tomography provides topological insights into mutant huntingtin exon 1 and polyQ aggregates.Semantic proximity Read

Structural insight into transmissive mutant huntingtin species by correlative light and electron microscopy and cryo-electron tomography.Semantic proximity Read

In Situ Architecture and Cellular Interactions of PolyQ Inclusions.Semantic proximity Read

Pioneering Organelle Structural Biology: Golgi Apparatus Dysfunction in Parkinson’s Disease, Neurodevelopmental Disorders, and CancerSemantic proximity Read

Structure-function dissection of huntingtin exon 1 identifies a PRD-driven modifier of neuronal toxicity in Huntington’s diseaseSemantic proximity Read

Proteomics of Huntington's disease-affected human embryonic stem cells reveals an evolving pathology involving mitochondrial dysfunction and metabolic disturbances.Semantic proximity Read

Structure of the Thin Filament in Human iPSC-derived Cardiomyocytes and its Response to Heart DiseaseSemantic proximity Read

Ultrastructural Dynamics of Dopaminergic Presynaptic Release Sites revealed by Cryo-correlative Light and Electron MicroscopySemantic proximity Read

<i>In situ</i> cryo-ET visualization of mitochondrial depolarization and mitophagic engulfmentSemantic proximity Read

A robust workflow for 3D imaging of human mitochondria using cryo-electron tomographySemantic proximity Read