Membranes as targets and modifiers of mutant huntingtin aggregation.

Abstract excerpt

Huntington's disease (HD) is a neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin (HTT) gene, resulting in an expanded polyglutamine (polyQ) tract in HTT protein. Expanded polyQ tracts cause mutant HTT (mHTT) to aggregate and accumulate as cellular inclusions. Recent studies highlight the interactions between mHTT and different cellular membranes that contribute to HD pathogenesis....

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• Cell Membrane
• HTT gene
• Huntingtin Protein
• Huntington Disease
• Mutation
• Peptides