Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mitochondria "Shackled" by Mutant Huntingtin: Analysis of Morphological Alterations and Disruptions of Intracellular Transport.

Biochemistry. Biokhimiia - 1 Feb 2026

Pasko Vyacheslav I, Churkina Aleksandra S, Belikova Lilia D, Shakhov Anton S, Lavrushkina Svetlana V, Burakov Anton V, Bogomazova Alexandra N, Lagarkova Maria A, Alieva Irina B

Abstract excerpt

Mitochondria are semi-autonomous, multifunctional organelles that supply cells with energy. They are highly dynamic structures, capable of moving, fusing, dividing, and forming branched networks. The number, density, and complexity of mitochondrial network are unique to each cell type and reflect cellular demands for ATP and other mitochondria-dependent metabolites. Mitochondrial dysfunction is a hallmark of many...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Transport
Share to Cytoskeleton

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HTT gene

Share to Huntingtin Protein

Share to Huntington Disease

Share to Microtubules

Share to Mitochondria

Share to Mutation

Source

Identifiers

PMID: 41843843
DOI: 10.1134/S0006297925602850

Genes

HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitochondria "Shackled" by Mutant Huntingtin: Analysis of Morphological Alterations and Disruptions of Intracellular Transport.PMID 41843843Read ↗

Principles of the mitochondrial fusion and fission cycle in neurons.Semantic proximity Read ↗

Mutant huntingtin, abnormal mitochondrial dynamics, defective axonal transport of mitochondria, and selective synaptic degeneration in Huntington's disease.Semantic proximity Read ↗

Mutant huntingtin aggregates impair mitochondrial movement and trafficking in cortical neurons.Semantic proximity Read ↗

Mutant huntingtin and mitochondrial dysfunction.Semantic proximity Read ↗

Serum Response Factor (SRF)-cofilin-actin signaling axis modulates mitochondrial dynamics.Semantic proximity Read ↗

Live cell imaging and CLEM reveals effects of Mutant Huntingtin Aggregation ProcessSemantic proximity Read ↗

MitoCellPhe reveals mitochondrial morphologies in single fibroblasts and clustered stem cells.Semantic proximity Read ↗

Mitochondrial loss, dysfunction and altered dynamics in Huntington's diseaseSemantic proximity Read ↗

Huntington's disease affects mitochondrial network dynamics predisposing to pathogenic mitochondrial DNA mutations.Semantic proximity Read ↗

Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro.Semantic proximity Read ↗

Mitochondrial structural and functional dynamics in Huntington's diseaseSemantic proximity Read ↗

Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.