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Article

In Situ Architecture and Cellular Interactions of PolyQ Inclusions.

Cell - 21 Sept 2017

Bäuerlein Felix J B, Saha Itika, Mishra Archana, Kalemanov Maria, Martínez-Sánchez Antonio, Klein Rüdiger, Dudanova Irina, Hipp Mark S, Hartl F Ulrich, Baumeister Wolfgang, Fernández-Busnadiego Rubén

Abstract excerpt

Expression of many disease-related aggregation-prone proteins results in cytotoxicity and the formation of large intracellular inclusion bodies. To gain insight into the role of inclusions in pathology and the in situ structure of protein aggregates inside cells, we employ advanced cryo-electron tomography methods to analyze the structure of inclusions formed by polyglutamine (polyQ)-expanded huntingtin exon 1...

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PMID: 28890085
DOI: 10.1016/j.cell.2017.08.009

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