Article

Elevation of the mechanically-sensitive protein emerin links nuclear mechanotransduction to tau-induced cytoskeletal remodeling in neurons

2025-10-15

Abstract excerpt

<h4>ABSTRACT</h4> Tauopathies are a group of neurodegenerative disorders, including Alzheimer’s disease, that are neuropathologically defined by deposition of pathological forms of tau in the brain. While tau is reported to drive neurotoxicity by negatively affecting cytoskeletal, nucleoskeletal, and genomic architecture, the mechanisms mediating tau-induced dysfunction of the cytoskeleton and nucleoskeleton are...

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Literature Corpus work: e5aa9a28-5f39-5ed4-96a5-b49c1ab9dd42
DOI: 10.1101/2025.10.15.682650

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