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Mutant huntingtin aggregates impair mitochondrial movement and trafficking in cortical neurons.

Neurobiology of disease - 1 May 2006

Chang Diane T W, Rintoul Gordon L, Pandipati Sruthi, Reynolds Ian J

Abstract excerpt

Huntington's disease (HD) is a neurodegenerative disorder caused by a polyglutamine repeat in the huntingtin gene (Htt). Mitochondrial defects and protein aggregates are characteristic of affected neurons. Recent studies suggest that these aggregates impair cellular transport mechanisms by interacting with cytoskeletal components and molecular motors. Here, we investigated whether mutant Htt alters mitochondrial...

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Identifiers

PMID: 16473015
DOI: 10.1016/j.nbd.2005.12.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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