Article
CryoET reveals organelle phenotypes in huntington disease patient iPSC-derived and mouse primary neurons.
Nature communications - 8 Feb 2023
Wu Gong-Her, Smith-Geater Charlene, Galaz-Montoya Jesús G, Gu Yingli, Gupte Sanket R, Aviner Ranen, Mitchell Patrick G, Hsu Joy, Miramontes Ricardo, Wang Keona Q, Geller Nicolette R, Hou Cathy, Danita Cristina, Joubert Lydia-Marie, Schmid Michael F, Yeung Serena, Frydman Judith, Mobley William, Wu Chengbiao, Thompson Leslie M, Chiu Wah
Abstract excerpt
Huntington's disease (HD) is caused by an expanded CAG repeat in the huntingtin gene, yielding a Huntingtin protein with an expanded polyglutamine tract. While experiments with patient-derived induced pluripotent stem cells (iPSCs) can help understand disease, defining pathological biomarkers remains challenging. Here, we used cryogenic electron tomography to visualize neurites in HD patient iPSC-derived neurons...
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