Article

CryoET Reveals Organelle Phenotypes in Huntington Disease Patient iPSC-Derived and Mouse Primary Neurons

2022-04-08

Abstract excerpt

<title>Abstract</title> <p>Huntington’s Disease (HD) is caused by an expanded CAG repeat in the huntingtin gene, yielding a Huntingtin protein with an expanded polyglutamine tract. Patient-derived induced pluripotent stem cells (iPSCs) can help understand disease; however, defining pathological biomarkers is challenging. Here, we used cryogenic electron tomography to visualize neurites in HD patient iPSC-derived...

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Literature Corpus work: f1c8fe7b-5ace-58f0-93f2-9872c491fa37
DOI: 10.21203/rs.3.rs-1493068/v1

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