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Article

Structural insight into transmissive mutant huntingtin species by correlative light and electron microscopy and cryo-electron tomography.

Biochemical and biophysical research communications - 30 Jun 2021

Kuang Xuyuan, Nunn Kyle, Jiang Jennifer, Castellano Paul, Hardikar Uttara, Horgan Arianna, Kong Joyce, Tan Zhiqun, Dai Wei

Abstract excerpt

Aggregates of mutant huntingtin (mHTT) containing an expanded polyglutamine (polyQ) tract are hallmarks of Huntington's Disease (HD). Studies have shown that mHTT can spread between cells, leading to the propagation of misfolded protein pathology. However, the structure of transmissive mHTT species, and the molecular mechanisms underlying their transmission remain unknown. Using correlative light and electron...

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Identifiers

PMID: 33984771
DOI: 10.1016/j.bbrc.2021.04.124
PMCID: PMC8176346

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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