Article

HspB8 prevents aberrant phase transitions of FUS by chaperoning its folded RNA binding domain

2021-04-13

Abstract excerpt

<h4>Summary</h4> Aberrant liquid-to-solid phase transitions of biomolecular condensates have been linked to various neurodegenerative diseases. However, the underlying molecular interactions that drive aging remain enigmatic. Here, we develop quantitative time-resolved crosslinking mass spectrometry to monitor protein interactions and dynamics inside condensates formed by the protein fused in sarcoma (FUS). We id...

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Literature Corpus work: 5204f447-d0ce-5dc7-a791-fee901c5badd
DOI: 10.1101/2021.04.13.439588

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