Article

Breaking β-sheets in FUS prion-like domain preserves phase separation and function but prevents aggregation and toxicity

2026-02-18

Abstract excerpt

The RNA-binding protein Fused in Sarcoma (FUS) undergoes phase separation associated with RNA processing. However, the prion-like low complexity (LC) domain of FUS forms solid-like aggregates in neurodegenerative diseases. Whether the formation of β-sheet structure associated with pathology is also physiologically/functionally relevant is debated. Similarly, if mislocalization alone or concomitant aggregation is r...

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Literature Corpus work: bd4922d6-f931-54bd-943f-8c8a0e0a70e5
DOI: 10.64898/2026.02.17.706410

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