Article

Sequence Complexity and Monomer Rigidity Control the Morphologies and Aging Dynamics of Protein Aggregates

2024-06-12

Abstract excerpt

Understanding the biophysical basis of protein aggregation is important in biology because of the potential link to several misfolding diseases. Although experiments have shown that protein aggregates adopt a variety of morphologies, the dynamics of their formation are less well characterized. Here, we introduce a minimal model to explore the dependence of the aggregation dynamics on the structural and sequence fe...

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Literature Corpus work: 9837ac9d-3b10-52cf-9d63-15194b7fcd43
DOI: 10.1101/2024.06.10.598316

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