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Article

HspB8 prevents aberrant phase transitions of FUS by chaperoning its folded RNA-binding domain.

eLife - 6 Sept 2021

Boczek Edgar E, Fürsch Julius, Niedermeier Marie Laura, Jawerth Louise, Jahnel Marcus, Ruer-Gruß Martine, Kammer Kai-Michael, Heid Peter, Mediani Laura, Wang Jie, Yan Xiao, Pozniakovski Andrej, Poser Ina, Mateju Daniel, Hubatsch Lars, Carra Serena, Alberti Simon, Hyman Anthony A, Stengel Florian

Abstract excerpt

Aberrant liquid-to-solid phase transitions of biomolecular condensates have been linked to various neurodegenerative diseases. However, the underlying molecular interactions that drive aging remain enigmatic. Here, we develop quantitative time-resolved crosslinking mass spectrometry to monitor protein interactions and dynamics inside condensates formed by the protein fused in sarcoma (FUS). We identify misfolding...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34487489
DOI: 10.7554/eLife.69377
PMCID: PMC8510580

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