Article
Tunable metastability of condensates reconciles their dual roles in amyloid fibril formation.
Molecular cell - 5 Jun 2025
Das Tapojyoti, Zaidi Fatima K, Farag Mina, Ruff Kiersten M, Mahendran Tharun Selvam, Singh Anurag, Gui Xinrui, Messing James, Taylor J Paul, Banerjee Priya R, Pappu Rohit V, Mittag Tanja
Abstract excerpt
Stress granules form via co-condensation of RNA-binding proteins (RBPs) containing prion-like low-complexity domains (PLCDs) with RNA molecules. Homotypic interactions among PLCDs can drive amyloid fibril formation that is enhanced by amyotrophic lateral sclerosis (ALS)-associated mutations. We report that condensation- versus fibril-driving homotypic interactions are separable for A1-LCD, the PLCD of hnRNPA1....
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