Article

Real-Time Observation of Structure and Dynamics during the Liquid-to-Solid Transition of FUS LC

2020-10-19

Abstract excerpt

Many of the proteins found in pathological protein fibrils also exhibit tendencies for liquid-liquid phase separation (LLPS) both in vitro and in cells. The mechanisms underlying the connection between these phase transitions have been challenging to study due to the heterogeneous and dynamic nature of the states formed during the maturation of LLPS protein droplets into gels and solid aggregates. Here, we interr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cc9ebb8e-0cfe-5c6e-a7b8-a7892d5baaed
DOI: 10.1101/2020.10.19.345710

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Real-Time Observation of Structure and Dynamics during the Liquid-to-Solid Transition of FUS LCDOI 10.1101/2020.10.19.345710Read

A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation.Semantic proximity Read

The physics of liquid-to-solid transitions in multi-domain protein condensatesSemantic proximity Read

Breaking β-sheets in FUS prion-like domain preserves phase separation and function but prevents aggregation and toxicitySemantic proximity Read

HspB8 prevents aberrant phase transitions of FUS by chaperoning its folded RNA binding domainSemantic proximity Read

The physiological and pathological biophysics of phase separation and gelation of RNA binding proteins in amyotrophic lateral sclerosis and fronto-temporal lobar degeneration.Semantic proximity Read

The Low Complexity Domain of the FUS RNA Binding Protein Self-assembles via the Mutually Exclusive Use of Two Distinct Cross-β CoresSemantic proximity Read

The Role of Post-Translational Modifications on Prion-Like Aggregation and Liquid-Phase Separation of FUS.Semantic proximity Read

HspB8 prevents aberrant phase transitions of FUS by chaperoning its folded RNA-binding domain.Semantic proximity Read

ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function.Semantic proximity Read

The phase separation-dependent FUS interactome reveals nuclear and cytoplasmic function of liquid-liquid phase separationSemantic proximity Read

The phase separation-dependent FUS interactome reveals nuclear and cytoplasmic function of liquid–liquid phase separationSemantic proximity Read

ALS-causing hPFN1 mutants differentially disrupt LLPS of FUS prion-like domain.Semantic proximity Read