Article

SKEMPI 2.0: An updated benchmark of changes in protein-protein binding energy, kinetics and thermodynamics upon mutation

2018-06-07

Abstract excerpt

<h4>Motivation</h4> Understanding the relationship between the sequence, structure, binding energy, binding kinetics and binding thermodynamics of protein-protein interactions is crucial to understanding cellular signaling, the assembly and regulation of molecular complexes, the mechanisms through which mutations lead to disease, and protein engineering. <h4>Results</h4> We present SKEMPI 2.0, a major update to...

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Literature Corpus work: a6d17ea2-6fd1-55b2-be36-6ed3c7ffe671
DOI: 10.1101/341735

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