Article

The genetic architecture of protein interaction affinity and specificity

2023-10-20

Abstract excerpt

Proteins function in crowded cellular environments in which they must bind to specific target proteins but also avoid binding to many other off-target proteins. In large protein families this task is particularly challenging because many off-target proteins have very similar structures. How this specificity of physical protein-protein interactions in cellular networks is encoded and evolves is not very well unders...

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Literature Corpus work: 944a1c1c-e4bb-5050-b6cb-b1de58e5a57c
DOI: 10.1101/2023.10.17.562688

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