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Article

Tandem Domains with Tuned Interactions Are a Powerful Biological Design Principle.

PLoS biology - 1 Jan 2015

Nussinov Ruth, Tsai Chung-Jung

Abstract excerpt

Allosteric effects of mutations, ligand binding, or post-translational modifications on protein function occur through changes to the protein's shape, or conformation. In a cell, there are many copies of the same protein, all experiencing these perturbations in a dynamic fashion and fluctuating through different conformations and activity states. According to the "conformational selection and population shift"...

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Identifiers

PMID: 26618518
DOI: 10.1371/journal.pbio.1002306
PMCID: PMC4664463

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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