Allosteric and energetic remodeling of a PDZ domain by protein domain extensions.

Abstract excerpt

Many functions of proteins are performed by independently folding structural units called domains. These domains are structurally conserved but not identical in different proteins. Here, to understand the consequences for regulation and evolvability of domain extensions, we quantify the energetic effects of two extensions in a model protein domain. Quantifying abundance and ligand binding for >190,000 protein...

Topics

• PDZ Domains
• Allosteric Regulation
• Mutation
• Thermodynamics
• Models, Molecular
• Protein Folding
• Protein Binding
• Proteins
• Ligands
• Protein Domains