Article
Rewiring Ancient Residue Interaction Networks Drove the Evolution of Specificity in Steroid Receptors.
Structure (London, England : 1993) - 4 Feb 2020
Okafor C Denise, Hercules David, Kell Steven A, Ortlund Eric A
Abstract excerpt
Understanding how changes in amino acid sequence alter protein dynamics and allosteric signaling would illuminate strategies for protein design. To gain insight into this process, we have combined molecular dynamics simulations with ancestral sequence reconstruction to explore conformational dynamics in two ancient steroid receptors (SRs) to determine how allosteric signaling pathways were altered over evolution...
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