Article

A complete map of specificity encoding enables reprogramming of a protein interaction

2024-04-25

Abstract excerpt

The human genome encodes the affinities and specificities of >half a million molecular interactions. Changes in specificity drive evolution, disease and therapeutic efficacy, but how specificity is encoded and reprogrammed is not well understood. Here we present a complete map of the encoding of specificity in a protein sequence and how mutations quantitatively interact to reprogram binding. By measuring >200,000...

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Identifiers and source

Literature Corpus work: 3292a942-f391-52ea-a433-b4a6b0abadfd
DOI: 10.1101/2024.04.25.591103

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