Article

Allosteric and Energetic Remodeling by Protein Domain Extensions

2025-07-29

Abstract excerpt

Many functions of proteins are performed by independently folding structural units called domains. The structures of domains are conserved during evolution but they are not identical. For example, the >270 human PDZ domains vary in the number of secondary structure elements and in the length of loops. An important but largely unexplored question is the impact of these extensions on protein energy landscapes: beyon...

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Identifiers and source

Literature Corpus work: 4aa79743-06af-5d24-966f-85a903260a18
DOI: 10.1101/2025.07.24.666590

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