Article

Distinct immune-effector and metabolic profile of CD8<sup>+</sup> T Cells in patients with autoimmune polyarthritis induced by therapy with immune-checkpoint inhibitors

2022-03-12

Abstract excerpt

<h4>Objectives</h4> Rheumatic immune-related adverse events (irAE) such as (poly)arthritis in patients undergoing immune checkpoint inhibitor (ICI) treatment pose a major clinical challenge. ICI-therapy improves CD8+ T cell (CD8) function, but CD8 contribute to chronic inflammation in autoimmune arthritis (AA). Thus, we studied whether immune-functional and metabolic changes in CD8 explain the development of muscu...

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Literature Corpus work: a7d6a507-12c9-5fb0-be28-51ca8292e6b0
DOI: 10.1101/2022.03.09.22272158

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Distinct immune-effector and metabolic profile of CD8<sup>+</sup> T Cells in patients with autoimmune polyarthritis induced by therapy with immune-checkpoint inhibitorsDOI 10.1101/2022.03.09.22272158Read

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