Article

Reduction of pro-inflammatory effector functions through remodeling of fatty acid metabolism in CD8<sup>+</sup> T-cells from Rheumatoid Arthritis patients

2022-09-23

Abstract excerpt

<h4>Objectives</h4> RA CD8 + T-cells (CD8) maintain their effector pro-inflammatory phenotype by changing their metabolism towards aerobic glycolysis. However, their massive energetic and biosynthetic needs may require additional substrates to furnish this high demand. Since systemic alterations in lipid metabolism have been reported in RA patients, we explored the role of fatty acid (FA) metabolism in CD8 to iden...

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Literature Corpus work: 9a9dd485-2f53-514d-8930-d26ae12d20ff
DOI: 10.1101/2022.09.22.22280236

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