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Article

PD-1+CD8+ T cells are clonally expanding effectors in human chronic inflammation

2 Aug 2018

Abstract excerpt

Chronic inflammatory diseases are characterized by recurrent inflammatory attacks in the tissues mediated by autoreactive T cells. Identity and functional programming of CD8+ T cells at the target site of inflammation still remain elusive. One key question is whether, in these antigen-rich environments, chronic stimulation leads to CD8+ T cell exhaustion comparable to what is observed in infectious disease...

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PMID: 30198907
DOI: 10.1172/jci96107

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