Article

JAK/STAT Inhibition Reprograms T Cell Activation and Metabolism in Inflammatory Arthritis Patients

2025-11-27

Abstract excerpt

<title>Abstract</title> <p>Objectives: Inflammatory arthritis (IA) is a group of autoimmune diseases characterised by joint inflammation and progressive damage, thus impairing the patient’s quality of life. The JAK/STAT pathway inhibitor Tofacitinib has been successfully introduced into the clinic to treat patients with IA, however its direct effect on T cell responses is widely unknown. This study aims to assess...

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Literature Corpus work: 64b557a9-8caa-5b3a-94d5-7b1c816d8bf0
DOI: 10.21203/rs.3.rs-8050605/v1

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