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Clonally expanded CD38 <sup>hi</sup> cytotoxic CD8 T cells define the T cell infiltrate in checkpoint inhibitor-associated arthritis

2021-10-20

Abstract excerpt

Immune checkpoint inhibitor (ICI) therapies that promote T cell activation have improved outcomes for advanced malignancies yet also elicit harmful autoimmune reactions. The T cell mechanisms mediating these iatrogenic autoimmune events remain unclear. Here we assayed T cells from joints of patients affected by ICI-induced inflammatory arthritis (ICI-arthritis), which can present clinically indistinguishable from...

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Literature Corpus work
1adadb23-0470-5fae-a4bb-fe075b5f365b
DOI
10.1101/2021.10.19.464961
Open publication

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Clonally expanded CD38 <sup>hi</sup> cytotoxic CD8 T cells define the T cell infiltrate in checkpoint inhibitor-associated arthritisDOI 10.1101/2021.10.19.464961
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