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Article

Melanoma causes phenotypic modulations and metabolic switches of iNKT cells influencing clinical outcomes.

Frontiers in immunology - 1 Jan 2025

Degeorges Emmanuelle, Mouret Stéphane, Girard Pauline, Niveau Camille, Cettour-Cave Mélanie, Sosa Cuevas Eleonora, De Fraipont Florence, Charles Julie, Saas Philippe, Aspord Caroline

Abstract excerpt

Introduction: Invariant NKT (iNKT) cells are crucial effectors in cancer immunosurveillance, due to their immunomodulatory potential through a broad range of effector and regulatory functions. Yet, their use as targets or vectors for cancer immunotherapy in cancer yielded inconsistent outcomes, due to potential tumor immune escape mechanisms. Limited information is available regarding the potential dysfunctions...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41562072
DOI: 10.3389/fimmu.2025.1703754
PMCID: PMC12813057

Genes

CTLA4
LAG3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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