Article

The STORE.2 model of the T cell proliferative phase considering c-Myc

2025-06-08

Abstract excerpt

<h4>ABSTRACT</h4> The generation of antigen-specific CD8 + T cell responses is dictated by the affinity of the cognate antigen, the stimulatory capacity of antigen presenting cells (APCs), and the metabolic pathways required for rapid cell proliferation. The complexity of these pathways is a significant challenge in designing vaccines against diseases that require a protective CD8 + T cell response. To understa...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a7b1fffc-6acc-50a8-94ff-4cf5553c1e3c
DOI: 10.1101/2025.06.05.658086

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The STORE.2 model of the T cell proliferative phase considering c-MycDOI 10.1101/2025.06.05.658086Read

Multi-Approach and Multi-Scale Model of CD4+ T Cells Predicts Switch-Like and Oscillatory Emergent Behaviors in Inflammatory Response to InfectionSemantic proximity Read

A comparative mathematical modeling study of phenotypic approaches to T cell activation.Semantic proximity Read

A Multiscale Spatial Modeling Framework for the Germinal Center ResponseSemantic proximity Read

A next generation mathematical model for the in vitro to clinical translation of T-cell engagersSemantic proximity Read

A Minimal Model Framework for Robust CAR-T Cell and Oncolytic Virus Combination TherapySemantic proximity Read

Dynamic estimation of metabolic state during CAR T cell production and the relationship of early metabolism to final therapeutic productSemantic proximity Read

Initiation of primary T cell—B cell interactions and early antibody responses in an organized microphysiological model of the human lymph nodeSemantic proximity Read

Fuel and brake of memory T cell inflationSemantic proximity Read

Perfect adaptation of CD8 <sup>+</sup> T cell responses to constant antigen input over a wide range of affinity is overcome by costimulationSemantic proximity Read

Augmenting TCR signal strength and ICOS costimulation results in metabolically fit and therapeutically potent human CAR Th17 cell therapySemantic proximity Read

Induction of T-cell memory by a dendritic cell vaccine: a computational modelSemantic proximity Read

Dynamic mechanisms of time-of-day-dependent adaptive immunity and vaccination responsesSemantic proximity Read