Article

Perfect adaptation of CD8 <sup>+</sup> T cell responses to constant antigen input over a wide range of affinity is overcome by costimulation

2019-01-30

Abstract excerpt

Maintaining and limiting T cell responses to constant antigen stimulation is critical to control pathogens and maintain self-tolerance, respectively. Antigen recognition by T cell receptors (TCRs) induces signalling that activates T cells to produce cytokines and also leads to the downregulation of surface TCRs. In other systems, receptor downregulation can induce perfect adaptation to constant stimulation by a me...

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Literature Corpus work: f534097e-2612-59da-abe3-848de8d94783
DOI: 10.1101/535385

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